Association of myeloid-derived suppressor cells with hematopoietic recovery after high-dose chemotherapy in multiple myeloma
نویسندگان
چکیده
Myeloid-derived suppressor cells (MDSCs) play an important role in the immune response regulation many pathologies, primarily malignant tumors, but their hematopoietic stem cell engraftment and recovery after high-dose chemotherapy autologous transplantation remains practically unexplored. This study is aimed at studying correlation between number of MDSC subpopulations blood parameters stage patients with multiple myeloma (MM). Circulating MDSCs were assessed leukopenia (absolute leukocyte count peripheral (PB) > 1 x 10 9 /L) by flow cytometry. The transplanted CD34 + CD45 was 4.38 6 /kg (IQR (3.1—5.6) /kg). duration from varied 8 to 18 days (Me 12 days). not associated cells/kg graft. relative monocytic (M-MDSCs, CD14 HLA-DR low/- ) directly correlated monocytes (R = 0.417, p 0.002). Granulocytic (PMN-MDSCs, Lin - CD33 CD66b characterized inverse -0.493, 0.0003) while association absolute neutrophils weak 0.273, 0.048). lymphocytes had PMN-MDSCs -0.347, 0.014) did correlate M-MDSCs. When analyzing leukopenia, this indicator revealed for percentage M-MDSCs 0.018 R -0.469, 0.0008, respectively). Multiple regression analysis showed dependence lymphopenia on proportion circulating (p 0.032). According data multivariate variance, significant factors leukopenia. At same time, such clinical as depth minimal residual disease status before transplantation, well MM stage, affect recovery. Thus, obtained results indicate a higher shorter positive early post-transplant period MM.
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ژورنال
عنوان ژورنال: ??????????? ???????????
سال: 2023
ISSN: ['2409-5788']
DOI: https://doi.org/10.15789/1563-0625-aom-2700